Key result
An increased left ventricular mass-to-volume ratio significantly increased the risk of total cardiovascular events, particularly in individuals <65 years (HR 3.69; 95% CI 1.34-10.10).
Cohort (n=5,004)
Effect estimate: HR 3.69 (95% CI 1.34 to 10.10)
p-value: p=0.013
Age-related left ventricular remodeling, characterized by an increased mass-to-volume ratio despite preserved ejection fraction, confers a significant risk for cardiovascular events, particularly when present earlier in life.
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May flag higher CV risk in adults <65; hypothesis-generating for trials on early remodeling intervention.
Cheng et al. (2009) conducted a cohort in Without overt cardiovascular disease (n=5,004). Highest mass-to-volume ratio quintile vs. Lowest mass-to-volume ratio quintile was evaluated on Total cardiovascular events (HR 3.69, 95% CI 1.34 to 10.10, p=0.013). An increased left ventricular mass-to-volume ratio significantly increased the risk of total cardiovascular events, particularly in individuals <65 years (HR 3.69; 95% CI 1.34-10.10).
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