Key result
Computational models of the heart link cellular structure to intact heart behavior, but require inclusion of metabolic and signal transduction pathways to understand disease processes.
Design
Review
Authors
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Models link cardiac structure to function but should not yet guide disease care; leaves open metabolic pathway integration.
Computational models of heart function provide a framework linking cellular structure to intact heart behavior, though further integration of metabolic and signaling pathways is needed.
Hunter et al. (2003) conducted a review in Heart function. Computational models of the heart was evaluated. Computational models of the heart link cellular structure to intact heart behavior, but require inclusion of metabolic and signal transduction pathways to understand disease processes.
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