Transverse stiffness: a method for estimation of myocardial wall stress.
Key result
Transverse stiffness was linearly related to in-plane wall stress during active contractions (p<0.001) and passively applied stress (p<0.001) in canine ventricular septa.
Population
6 arterially perfused canine ventricular septa
Design
Preclinical
Authors
Discussion
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Implication
Supports transverse stiffness for wall stress estimation in animal models; leaves open translation to clinical or human ventricular mechanics research.
Key Points
- The aim is to determine if transverse stiffness can accurately estimate myocardial wall stress.
- Six canine ventricular septa were mounted in a biaxial loading apparatus.
- Transverse indentation stress and strain were measured during active ventricular contractions.
- Statistical analysis was performed using ANOVA to assess relationships.
- Transverse stiffness varied from 1.2 to 11.7 g/mm2, linearly related to in-plane wall stress (p < 0.001).
- Transverse stiffness also correlated with passively applied wall stress (p < 0.001).
- Relations between active and passive stress were similar (mean slopes: 1.82 ± 0.36 vs. 1.45 ± 0.31, NS).
Structured PICO
P
Population
6 arterially perfused canine ventricular septa
I
Intervention
Measurement of transverse stiffness using a 7 mm diameter indentation probe during active contractions and after cardioplegia
O
Outcome
Relationship between transverse stiffness and in-plane wall stresssurrogate
Main Result
p-value: p=<0.001
Transverse stiffness is linearly proportional to in-plane myocardial wall stress, suggesting it can serve as a valid method to estimate regional ventricular wall stress.
Cite This Study
Halperin et al. (1987) studied Myocardial wall stress estimation (n=6). Transverse stiffness measurement vs. In-plane wall stress was evaluated on Relationship between transverse stiffness and in-plane wall stress (p=<0.001). Transverse stiffness was linearly related to in-plane wall stress during active contractions (p<0.001) and passively applied stress (p<0.001) in canine ventricular septa.