August 28, 2002JAMA
Inflammatory Biomarkers, Hormone Replacement Therapy, and Incident Coronary Heart Disease
Key result
Baseline CRP and IL-6 levels independently predicted incident CHD among postmenopausal women, with the highest vs lowest CRP quartile yielding an OR of 2.3 (95% CI 1.4-3.7; P=0.002).
Why the study?
Do baseline levels of CRP and IL-6 predict incident CHD in postmenopausal women, and does HRT use modify this risk?
Population
608 postmenopausal women drawn from a cohort of 75,343 women with no history of cardiovascular disease or…
Comparison
Baseline levels of CRP and IL-6, and baseline… vs Lower baseline levels of CRP and IL-6, and…
Design
Case-control
Follow-up
median 2.9 years
Authors
Discussion
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Implication
Supports inflammation's role in postmenopausal CHD; leaves open whether CRP/IL-6 testing improves risk stratification beyond traditional factors.
Study Design
Type
Case-Control (n=608)
Multicenter
Yes
Structured PICO
Do baseline levels of CRP and IL-6 predict incident CHD in postmenopausal women, and does HRT use modify this risk?
P
Population
608 postmenopausal women (304 incident CHD cases, 304 matched controls) drawn from a cohort of 75,343 women with no history of cardiovascular disease or cancer.
I
Intervention
Baseline levels of CRP and IL-6, and baseline use of hormone replacement therapy (HRT)
C
Comparator
Lower baseline levels of CRP and IL-6, and nonuse of HRT
O
Outcome
Incidence of first myocardial infarction or death from CHDhard clinical
Main Result
Effect estimate: OR 2.3 (95% CI 1.4-3.7)
p-value: p=.002
CRP and IL-6 independently predict vascular events in apparently healthy postmenopausal women, and while HRT increases CRP, baseline inflammatory marker levels are stronger predictors of cardiovascular risk than HRT use.
Cite This Study
Pradhan et al. (2002) conducted a case-control in incident coronary heart disease (n=608). Baseline CRP and IL-6 levels vs. Lowest quartile was evaluated on Incidence of first myocardial infarction or death from CHD (OR 2.3, 95% CI 1.4-3.7, p=.002). Baseline CRP and IL-6 levels independently predicted incident CHD among postmenopausal women, with the highest vs lowest CRP quartile yielding an OR of 2.3 (95% CI 1.4-3.7; P=0.002).