Key result
Cardiac autoantibodies appear in most familial and ~50% of sporadic ARVC cases, suggesting autoimmunity.
Why the study?
Because myocarditis has been reported in ARVC, the study sought evidence for autoimmunity by assessing AHAs and AIDAs in ARVC.
Are anti-heart autoantibodies and anti-intercalated disk autoantibodies present in patients with arrhythmogenic right ventricular cardiomyopathy and their relatives?
Observational (n=742)
Are anti-heart autoantibodies and anti-intercalated disk autoantibodies present in patients with arrhythmogenic right ventricular cardiomyopathy and their relatives?
p-value: p==0.007
The presence of anti-heart and anti-intercalated disk autoantibodies in ARVC patients and affected relatives suggests an autoimmune component to the disease that correlates with severity.
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Supports autoimmune contribution to ARVC; hypothesis-generating and requires longitudinal validation before clinical use.
Caforio et al. (2020) conducted an observational in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (n=742). Serum anti-heart autoantibodies (AHAs) and anti-intercalated disk autoantibodies (AIDAs) testing vs. Controls with noninflammatory cardiac disease, ischemic heart failure, and healthy blood donors was evaluated on Presence of AHAs and AIDAs (p==0.007). Serum anti-heart and anti-intercalated disk autoantibodies were present in the majority of familial and almost half of sporadic ARVC cases, providing evidence of autoimmunity (P=0.007).
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