Key result
High BMI did not significantly increase the risk of cardiovascular events in patients with chronic kidney disease not on dialysis (adjusted HR 1.36; 95% CI 0.57-3.14; p=0.50).
Why the study?
Does high BMI increase the risk of cardiovascular events, dialysis initiation, and coronary artery calcification in patients with chronic kidney disease not on dialysis?
Cohort (n=471)
Does high BMI increase the risk of cardiovascular events, dialysis initiation, and coronary artery calcification in patients with chronic kidney disease not on dialysis?
Effect estimate: HR 1.36 (95% CI 0.57-3.14)
Absolute Event Rate: 21.3% vs 13.5%
p-value: p=0.50
In CKD patients not on dialysis, high BMI was not an independent predictor of cardiovascular events or coronary calcification, but it increased the risk for dialysis initiation when accounting for baseline GFR.
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High BMI was not independently linked to CV events in non-dialysis CKD; leaves open a GFR interaction for dialysis initiation.
Russo et al. (2014) conducted a cohort in Chronic kidney disease not on dialysis (n=471). High BMI vs. Normal BMI was evaluated on Cardiovascular events (HR 1.36, 95% CI 0.57-3.14, p=0.50). High BMI did not significantly increase the risk of cardiovascular events in patients with chronic kidney disease not on dialysis (adjusted HR 1.36; 95% CI 0.57-3.14; p=0.50).
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