Why the study?
Does concurrent use of aspirin and ibuprofen increase the risk of myocardial infarction compared with aspirin alone in patients receiving outpatient prescriptions?
Population
14,098 patients issued outpatient prescriptions for aspirin or ibuprofen between January 1, 1990, and…
Comparison
Concurrent use of aspirin and ibuprofen vs Aspirin alone
Design
Case-control
Authors
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No increased MI risk seen with aspirin-ibuprofen co-use; leaves open whether this challenges lab concerns or reflects observational confounding.
Does concurrent use of aspirin and ibuprofen increase the risk of myocardial infarction compared with aspirin alone in patients receiving outpatient prescriptions?
Concurrent use of aspirin and ibuprofen was not associated with an increased risk of myocardial infarction compared to aspirin alone, contradicting laboratory concerns of a harmful interaction.
Patel et al. (2004) studied this question.
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