Why the study?
Does concomitant ibuprofen use reduce the cardiovascular protective effects of low-dose aspirin?
Does concomitant ibuprofen use reduce the cardiovascular protective effects of low-dose aspirin?
Patients taking low-dose aspirin for cardiovascular protection should be advised to avoid chronic ibuprofen use due to a likely adverse interaction.
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May warrant caution with chronic ibuprofen in high-risk aspirin users; leaves open prospective confirmation of interaction.
MacDonald et al. (2006) studied this question.
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