Why the study?
Does ibuprofen reduce the magnitude and duration of aspirin's inhibition of platelet aggregation in healthy volunteers and patients on secondary stroke prophylaxis?
Population
10 healthy volunteers and a cohort of 28 patients treated with aspirin for secondary stroke prophylaxis…
Comparison
Ibuprofen 400 mg followed by aspirin 325 mg 2… vs Aspirin 325 mg alone, ibuprofen 400 mg alone…
Design
Cohort, 3 randomized treatment sessions (for the healthy volunteer phase)
Follow-up
27 months
Authors
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Concomitant ibuprofen may attenuate aspirin's antiplatelet effect in stroke patients; hypothesis-generating and requires randomized confirmation before practice change.
Does ibuprofen reduce the magnitude and duration of aspirin's inhibition of platelet aggregation in healthy volunteers and patients on secondary stroke prophylaxis?
Ibuprofen prevents the irreversible inhibition of platelet aggregation produced by aspirin, a pharmacodynamic interaction that can lead to recurrent ischemic events in patients on secondary stroke prophylaxis.
Gengo et al. (2007) studied this question.
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