Key result
Ibuprofen administration inhibited secondary platelet aggregation and serotonin release within 2 hours, with effects disappearing within 24 hours, in contrast to the irreversible effects of aspirin.
Why the study?
Does ibuprofen alter platelet function in vivo compared to aspirin?
Population
Unspecified subjects (in vivo and in vitro study)
Comparison
Ibuprofen (therapeutic dose) vs Aspirin
Design
Other
Follow-up
24 hours
Authors
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Ibuprofen may allow flexible periprocedural timing due to reversible effects; leaves open in vivo validation against aspirin.
Does ibuprofen alter platelet function in vivo compared to aspirin?
Ibuprofen causes a reversible inhibition of platelet function that resolves within 24 hours, unlike the irreversible effect of aspirin.
Yasuo Ikeda (1977) studied Healthy volunteers and arthritis patients (n=41). Ibuprofen vs. Baseline (pre-ingestion) was evaluated on Platelet aggregation and serotonin release. Ibuprofen administration inhibited secondary platelet aggregation and serotonin release within 2 hours, with effects disappearing within 24 hours, in contrast to the irreversible effects of aspirin.
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