Why the study?
Does ibuprofen affect platelet function and bleeding time in normal subjects and hemophiliac patients?
Population
Normal subjects and hemophiliac patients
Comparison
Ibuprofen 600 mg orally vs Lactose placebo
Design
RCT, random, double-blind
Follow-up
24 hours
Authors
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Ibuprofen may be safer than aspirin for hemophiliacs; extends RCT evidence of differential platelet effects to this population.
Does ibuprofen affect platelet function and bleeding time in normal subjects and hemophiliac patients?
Ibuprofen transiently inhibits platelet aggregation without prolonging bleeding time in hemophiliac patients, suggesting it may be safer than older anti-inflammatory drugs in this population.
Mcintyre et al. (1978) studied this question.
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