Key result
A 7-day course of ibuprofen (600 mg every 8 hours) induced platelet dysfunction in 7 of 11 healthy volunteers, which normalized within 24 hours after the last dose.
Why the study?
Does platelet dysfunction persist beyond 24 hours after discontinuing a 7-day course of ibuprofen in healthy adults?
Population
11 healthy adult volunteers
Comparison
Ibuprofen 600 mg orally every 8 hours for 7 days vs Baseline platelet function (pre-ibuprofen)
Design
Cohort
Follow-up
Serial testing up to 24 hours after last dose
Authors
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Short-course ibuprofen may normalize platelet function within 24 hours; challenges 1-week preoperative hold but leaves open relevance to surgical outcomes.
Cohort (n=11)
No
Does platelet dysfunction persist beyond 24 hours after discontinuing a 7-day course of ibuprofen in healthy adults?
Platelet function normalizes within 24 hours after stopping a 7-day course of ibuprofen, challenging the routine clinical advice to discontinue NSAIDs 1 week before surgical procedures.
Goldenberg et al. (2005) conducted a cohort in Healthy volunteers (n=11). Ibuprofen was evaluated on Duration of ibuprofen-induced platelet dysfunction measured by PFA-100. A 7-day course of ibuprofen (600 mg every 8 hours) induced platelet dysfunction in 7 of 11 healthy volunteers, which normalized within 24 hours after the last dose.
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