Key result
Acetaminophen had no effect on bleeding time or platelet aggregation, in contrast to aspirin which significantly increased bleeding time and caused platelet aggregation abnormalities.
Why the study?
Does acetaminophen compared to aspirin affect hemostasis in normal volunteers and hemophiliac patients?
Population
Normal volunteers and hemophiliac patients
Comparison
Acetaminophen vs Aspirin (single dose; 7-day course 1,950 mg daily)
Design
Other
Follow-up
up to 6 weeks
Authors
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May support acetaminophen when hemostasis matters; leaves open confirmation in larger patient cohorts.
Does acetaminophen compared to aspirin affect hemostasis in normal volunteers and hemophiliac patients?
Acetaminophen does not affect hemostasis, making it a suitable analgesic and antipyretic when bleeding risk is a concern.
C. Harold Mielke (1976) studied Normal volunteers and hemophiliac patients. Acetaminophen vs. Aspirin was evaluated on Bleeding time, platelet aggregation, and platelet factor 3 release. Acetaminophen had no effect on bleeding time or platelet aggregation, in contrast to aspirin which significantly increased bleeding time and caused platelet aggregation abnormalities.
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