Why the study?
Does aspirin alter bleeding time and platelet aggregation compared to sodium salicylate or placebo in normal male subjects?
Population
6 normal male subjects (for in vivo experiments) and platelet-rich plasma (for in vitro experiments)
Comparison
Aspirin vs Sodium salicylate and placebo
Design
Other
Follow-up
4-7 days
Authors
Loading...
Aspirin but not salicylate impairs hemostasis in healthy subjects; leaves open differential bleeding risks among NSAIDs in clinical populations.
Does aspirin alter bleeding time and platelet aggregation compared to sodium salicylate or placebo in normal male subjects?
Aspirin irreversibly prolongs bleeding time and inhibits platelet aggregation by decreasing ADP release, an effect not shared by sodium salicylate.
Weiss et al. (1968) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: