Key result
Intravenous acetaminophen dose-dependently inhibited platelet aggregation compared to placebo (median AUC 3.6 vs 25.7 x 10 area units for 30 mg/kg vs placebo; P<0.001).
Why the study?
Does intravenous acetaminophen inhibit platelet function in healthy male volunteers?
Population
13 healthy male volunteers, aged 19-26 years
Comparison
Acetaminophen 15, 22.5, or 30 mg/kg intravenously vs Placebo intravenously
Design
RCT, double-blind
Follow-up
90 minutes
Authors
Loading...
May warrant caution in patients with impaired hemostasis; extends antiplatelet observations to IV acetaminophen in an RCT.
RCT (n=13)
Double-blind
Does intravenous acetaminophen inhibit platelet function in healthy male volunteers?
p-value: p=<0.001
Intravenous acetaminophen exerts a dose-dependent antiaggregatory effect on platelets, which may be clinically relevant for patients with impaired hemostasis.
Munsterhjelm et al. (2005) conducted an RCT in Healthy volunteers (n=13). Acetaminophen vs. Placebo was evaluated on Platelet aggregation (area under the curve) triggered with 500 microm arachidonic acid at 10 min (p=<0.001). Intravenous acetaminophen dose-dependently inhibited platelet aggregation compared to placebo (median AUC 3.6 vs 25.7 x 10 area units for 30 mg/kg vs placebo; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: