Why the study?
Does paracetamol alone or in combination with diclofenac inhibit platelet function in vitro?
Population
Blood collected from healthy donors
Design
Preclinical
Authors
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May heighten perioperative bleeding risk; leaves open clinical relevance pending human studies.
Does paracetamol alone or in combination with diclofenac inhibit platelet function in vitro?
High doses of paracetamol and its combination with diclofenac synergistically inhibit platelet function in vitro, potentially increasing surgical bleeding risk.
Munsterhjelm et al. (2005) studied this question.