What does this research mean for the field?

Intravenous administration of ketoprofen, ketorolac, and diclofenac causes reversible platelet dysfunction, with diclofenac exhibiting the mildest effect and ketorolac causing prolonged dysfunction up to 24 hours. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1997Acta Anaesthesiologica Scandinavica

Comparison of the effect of intravenous ketoprofen, ketorolac and diclofenac on platelet function in volunteers

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Why the study?

Do intravenous ketoprofen, ketorolac, and diclofenac differentially affect platelet function in healthy male volunteers?

Population

10 healthy male volunteers

Comparison

Intravenous ketoprofen 1.4 mg/kg, ketorolac 0.4… vs Active comparators

Design

RCT, randomized, double-blind

Follow-up

24 hours

Authors

TNTomi NiemiUniversity of Vaasa CTChristel TaxellHelsinki University Hospital PRPer H. RosenbergUniversity of Applied Sciences Wedel

Discussion

Member takes

Implication

Supports preferring IV diclofenac to limit platelet inhibition; extends NSAID comparisons to healthy volunteers in an RCT.

Structured PICO

Do intravenous ketoprofen, ketorolac, and diclofenac differentially affect platelet function in healthy male volunteers?

Population

10 healthy male volunteers (2 excluded from final analysis due to lack of secondary platelet aggregation at baseline)

Intervention

Intravenous ketoprofen 1.4 mg/kg, ketorolac 0.4 mg/kg, and diclofenac 1.1 mg/kg in saline on three different occasions at >1-week intervals

Comparator

Active comparators (crossover design comparing ketoprofen, ketorolac, and diclofenac against each other)

Outcome

Platelet function (adrenaline and ADP-induced platelet aggregation, bleeding time, platelet retention on glass beads) evaluated before, 2 hours, and 24 hours after infusionsurrogate

Intravenous diclofenac causes milder and shorter-lasting platelet dysfunction compared to ketoprofen and ketorolac in healthy volunteers.

Limitations

Small sample size
2 volunteers excluded from final analysis due to lack of secondary platelet aggregation at baseline

Cite This Study

Niemi et al. (1997) studied this question.

synapsesocial.com/papers/6a1e0943348274ea529fc51c https://doi.org/10.1111/j.1399-6576.1997.tb04657.x

Topics

Dual antiplatelet therapy

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Comparison of the effect of intravenous ketoprofen, ketorolac and diclofenac on platelet function in volunteers

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Comparison of the effect of intravenous ketoprofen, ketorolac and diclofenac on platelet function in volunteers

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider