Why the study?
Does intravenous ketorolac worsen platelet function in patients undergoing knee arthroscopy under spinal anesthesia?
Population
30 ASA physical status I patients undergoing spinal anesthesia for knee arthroscopy
Comparison
Ketorolac 60 mg IV given 15 min after skin… vs Placebo IV
Design
RCT, randomized
Follow-up
45 min after administration of study drug
Authors
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IV ketorolac impairs platelet function in arthroscopy; confirms antiplatelet effects and supports bleeding-risk caution.
Does intravenous ketorolac worsen platelet function in patients undergoing knee arthroscopy under spinal anesthesia?
A single intraoperative dose of IV ketorolac during spinal anesthesia impairs platelet function, increasing bleeding time and decreasing platelet aggregometry to collagen.
Thwaites et al. (1996) studied this question.
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