Why the study?
Does intravenous ketorolac worsen platelet function in ASA physical status I patients undergoing knee arthroscopy under general anesthesia?
Population
30 ASA physical status I patients undergoing general anesthesia for knee arthroscopy
Comparison
Ketorolac 60 mg IV given 15 min after skin… vs Placebo IV
Design
RCT, randomized
Follow-up
45 min after administration of study drug
Authors
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Ketorolac may be used without platelet-related bleeding concerns in ASA I patients under general anesthesia; challenges assumptions linking TxB2 suppression to hemostatic impairment.
Does intravenous ketorolac worsen platelet function in ASA physical status I patients undergoing knee arthroscopy under general anesthesia?
Intravenous ketorolac does not inhibit platelet function during general anesthesia and surgery despite near complete abolition of thromboxane B2 production.
Thwaites et al. (1995) studied this question.
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