Key result
Low CV health scores linked to ~187% higher risk of ESRD versus high scores.
Why the study?
Does a higher ideal cardiovascular health score prevent incident end-stage renal disease in a community-based cohort?
Cohort (n=91,443)
No
Does a higher ideal cardiovascular health score prevent incident end-stage renal disease in a community-based cohort?
Effect estimate: HR 2.87 (95% CI 1.53 to 5.39)
Absolute Event Rate: 7.06% vs 2.34%
A lower ideal cardiovascular health score is significantly associated with an increased risk of developing incident end-stage renal disease.
Low CVH score associated with higher ESRD risk; hypothesis-generating and requires prospective trials before practice change.
OBJECTIVES: To investigate an association between ideal cardiovascular health metrics (CVH) and the risk of developing end-stage renal disease (ESRD). SETTING: Community of Kailuan in Tangshan/China. PARTICIPANTS: We examined in a community-based longitudinal cohort study 91 443 participants without history of stroke or myocardial infarction at baseline in 2006-2007, with a glomerular filtration rate (GFR) ≥15 mL/min at baseline, and who participated in at least 1 of 3 follow-up examinations in 2008-2009, 2010-2011 and 2012-2013. INTERVENTIONS: CVH was measured by 7 key health factors (smoking, body mass index, physical activity, healthy dietary score, total cholesterol blood concentration, blood pressure, fasting blood glucose) each of which ranged between 'ideal' (2) and 'poor' (0). With a maximal CVH score of 14, the study participants were divided into categories of <5, 5-9 and 10-14 points. PRIMARY AND SECONDARY OUTCOME MEASURES: CHV, incidence of ESRD. RESULTS: Incidence of ESRD ranged from 7.06‰ in the lowest CVH category to 2.34‰ in the highest CVH category. After adjusting for age, sex, educational level, income, alcohol consumption and GFR, the lowest CVH category as compared with the highest CVH category had a significantly higher risk of incident ESRD (adjusted HR 2.87; 95% CI 1.53 to 5.39). For every decrease in group number of the cum-CVH score, the risk of ESRD increased by 20% (HR 1.20; 95% CI 1.13 to 1.28). The effect was consistent across sex and all age groups. CONCLUSIONS: A low CVH score significantly increased the risk of incident ESRD. Risk factors for cardiovascular events may also be associated with an increased risk for kidney failure.
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Han et al. (2016) conducted a cohort in Without history of stroke or myocardial infarction (n=91,443). Ideal cardiovascular health metrics (CVH) score vs. Highest CVH category (10-14 points) was evaluated on Incidence of ESRD (HR 2.87, 95% CI 1.53 to 5.39). A low cardiovascular health score (<5 points) was associated with a significantly higher risk of incident end-stage renal disease compared to a high score (10-14 points) (HR 2.87; 95% CI 1.53-5.39).
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