Key result
Each 1-unit increase in the ideal cardiovascular health score was associated with a significantly lower odds of having subclinical cardiovascular disease markers (OR 0.808).
Why the study?
Does a higher ideal cardiovascular health score reduce the presence of subclinical cardiovascular disease markers in adults without clinical CVD?
Cross-Sectional (n=3,009)
No
Does a higher ideal cardiovascular health score reduce the presence of subclinical cardiovascular disease markers in adults without clinical CVD?
Odds Ratio: 0.808 (95% CI 0.755–0.865)
p-value: p=<0.001
Higher ideal cardiovascular health scores are inversely associated with subclinical biomarkers and markers of cardiovascular disease in a Chinese population, highlighting the importance of primordial prevention.
Supports CVH promotion for lower subclinical markers; leaves open prospective effects in primary prevention.
BACKGROUND: Ideal cardiovascular health (CVH) is related to a low cardiovascular disease risk profile. This study aimed to investigate CVH metrics with both the biomarkers and markers of subclinical impairments of cardiovascular diseases (CVDs) in subjects from central south China. METHODS: The ideal CVH score (non-smoking status; ideal body mass index; regular physical activity; healthy diet; and an optimal serum cholesterol, blood pressure, and glucose profile; 1 point for each; total score: 0-7) was collected from 3009 participants without a history of CVDs. Subclinical biomarkers were assessed using C-reactive protein, homocysteine, and microalbuminuria. The presence of subclinical disease markers was defined as having at least one of the following: increased carotid intima-media thickness, carotid plaque, left ventricular hypertrophy, left ventricular systolic dysfunction, or a reduced ankle-brachial index. The association of biomarkers and markers with the CVH score was evaluated using multivariate logistic regression and linear regression analyses. RESULTS: Only 0.2% of the study participants met all 7 ideal CVH metrics (CVH score = 7). Compared to the female participants, the male participants had poorer CVH profiles and a higher incidence of subclinical lesions (P < 0.05). In the fully adjusted models, per 1-unit increase in the CVH score was inversely associated with the biomarker levels (β = -0.092 - -0.224, P < 0.05 for all) and the odds of the presence of markers (odds ratio, 0.808; 95% confidence interval, 0.755-0.865). Similar relationships were observed in the gender subgroups and were stronger in the females. CONCLUSION: A clear inverse association was observed between the biomarkers or markers of subclinical impairments and the CVH score in a central south Chinese population, implying the importance of ideal CVH for the primordial prevention of CVDs.
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Wang et al. (2017) conducted a cross-sectional in Subclinical cardiovascular disease (n=3,009). Ideal cardiovascular health (CVH) score vs. Lower CVH score was evaluated on Presence of subclinical disease markers (increased CIMT, carotid plaque, LV hypertrophy, LV systolic dysfunction, or reduced ABI) (OR 0.808, 95% CI 0.755-0.865, p=<0.001). Each 1-unit increase in the ideal cardiovascular health score was associated with a significantly lower odds of having subclinical cardiovascular disease markers (OR 0.808).
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