What is the clinical evidence from this study?

Study design: Observational. Population: Sudden cardiac death (n=5869). Intervention: Female sex vs. Male sex. Primary outcome: Ischemic heart disease as cause of sudden cardiac death (p=0.005).

What question did this study set out to answer?

This study aims to identify autopsy findings and causes of sudden cardiac death (SCD) among women and compare ECG characteristics between sexes.

February 19, 2019CirculationOpen Access

Sudden Cardiac Death in Women

Q: What are the key findings of this study?

Among subjects with sudden cardiac death, women were significantly older than men (70.1 vs 63.5 years) and more likely to have nonischemic causes of death (28.3% vs 24.3%, P=0.005).

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Key result

SCD strikes women ~7 years later than men and involves more nonischemic causes.

P=0.005
n=5,869

Why the study?

Sudden cardiac death mechanisms and risk markers are not as well defined for women compared to men.

What are the differences in autopsy findings, causes of death, and prior ECG characteristics between women and men with sudden cardiac death?

Population

5869 subjects with SCD in Northern Finland

Comparison

Women vs men with SCD

Design

Cohort study

Authors

MHM. Anette E. HaukilahtiElectrophysiology LHLauri HolmströmElectrophysiology JVJuha VähätaloElectrophysiology

Discussion

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Implication

Sex differences in SCD age and etiology warrant sex-specific risk caution; extends autopsy data but leaves open prospective validation.

Key Points

This study aims to identify autopsy findings and causes of sudden cardiac death (SCD) among women and compare ECG characteristics between sexes.
Analyzed clinical and autopsy data from 5869 subjects with SCD in Northern Finland (1998-2017).
Examined previously recorded ECGs in 1101 subjects, with 25.3% being women.
Utilized statistical analysis to compare causes of death and ECG findings by sex.
Female subjects were significantly older at SCD (70.1±13.1 years) compared to men (63.5±11.8 years), P<0.001.
The leading cause of death was ischemic heart disease in both sexes (71.7% in women vs. 75.7% in men, P=0.005).
Women showed a higher prevalence of primary myocardial fibrosis (5.2% vs. 2.6% in men, P<0.001) and were more likely to have a normal ECG prior to SCD (22.2% vs. 15.3% in men, P<0.001).

Study Design

Type

Observational (n=5,869)

Structured PICO

What are the differences in autopsy findings, causes of death, and prior ECG characteristics between women and men with sudden cardiac death?

Population

5,869 subjects with sudden cardiac death (SCD) in Northern Finland between 1998 and 2017. Prior ECGs were available in 1,101 subjects.

Comparator

Male subjects with sudden cardiac death

Outcome

Autopsy findings, causes of death, and prior ECG characteristicshard clinical

Main Result

Absolute Event Rate: 71.7% vs 75.7%

p-value: p=0.005

Women experiencing sudden cardiac death are older, more likely to have nonischemic causes, and more frequently have normal prior ECGs compared to men, highlighting sex-specific differences in SCD risk profiles.

Cite This Study

Haukilahti et al. (2019) conducted an observational in Sudden cardiac death (n=5,869). Female sex vs. Male sex was evaluated on Ischemic heart disease as cause of sudden cardiac death (p=0.005). Among subjects with sudden cardiac death, women were significantly older than men (70.1 vs 63.5 years) and more likely to have nonischemic causes of death (28.3% vs 24.3%, P=0.005).

synapsesocial.com/papers/6a0858591e0fcf4a43e8bbbe https://doi.org/10.1161/circulationaha.118.037702

Topics

Cardiomyopathy Women and heart disease

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Sudden Cardiac Death in Women

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Sudden Cardiac Death in Women

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider