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October 14, 2018Journal of Diabetes ResearchOpen Access

Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

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Why the study?

Does spironolactone improve cardiac oxidative stress, fibrosis, inflammation, and mitochondrial dysfunction in streptozotocin-induced diabetic rats?

Population

Streptozotocin-induced diabetic rats

Comparison

Spironolactone vs Streptozotocin + normal saline (STZ + NS group)

Design

Preclinical

Authors

WLWenjuan LiuWGWei GongMHMin He

Discussion

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Overview

Hypothesis-generating for spironolactone in diabetic cardiomyopathy; leaves open clinical translation in humans.

Structured PICO

Does spironolactone improve cardiac oxidative stress, fibrosis, inflammation, and mitochondrial dysfunction in streptozotocin-induced diabetic rats?

P
Population
Streptozotocin-induced diabetic rats
I
Intervention
Spironolactone
C
Comparator
Streptozotocin + normal saline (STZ + NS group)
O
Outcome
Mitochondrial morphological abnormalities, sarcoplasmic reticulum enlargement, cardiac oxidative stress, fibrosis, inflammation, and mitochondrial dysfunctionsurrogate

Spironolactone demonstrates cardioprotective effects in a rat model of diabetic cardiomyopathy by ameliorating mitochondrial dysfunction, fibrosis, oxidative stress, and inflammation.

Cite This Study

Liu et al. (2018) studied this question.

synapsesocial.com/papers/6a085bb73d5e33e4691082efhttps://doi.org/10.1155/2018/9232065
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