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July 30, 2020Molecular Nutrition & Food Research

Syringaresinol Protects against Type 1 Diabetic Cardiomyopathy by Alleviating Inflammation Responses, Cardiac Fibrosis, and Oxidative Stress

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Why the study?

Little is known about the pharmacodynamic effect of syringaresinol on modulating diabetic cardiomyopathy and its underlying molecular mechanism.

Does syringaresinol improve cardiac dysfunction and fibrosis in models of type 1 diabetic cardiomyopathy?

Population

STZ-induced type 1 diabetic mice and neonatal cardiomyocytes

Comparison

Oral syringaresinol vs control in vivo, and syringaresinol incubation vs high glucose in vitro

Design

In vivo and in vitro animal and cell study

Follow-up

8 weeks

Authors

LYLei YangLYLei YangLFLifeng Feng

Discussion

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Overview

SYR attenuates diabetic cardiomyopathy in mice; hypothesis-generating and leaves open human translation.

Structured PICO

Does syringaresinol improve cardiac dysfunction and fibrosis in models of type 1 diabetic cardiomyopathy?

P
Population
STZ-induced type 1 diabetic mice and neonatal cardiomyocytes
I
Intervention
Syringaresinol (SYR) administered orally every other day for 8 weeks (in vivo) and via incubation (in vitro)
O
Outcome
Cardiac dysfunction, hypertrophy, and fibrosissurrogate

Syringaresinol demonstrates protective effects against type 1 diabetic cardiomyopathy in preclinical models by modulating Keap1/Nrf2 and TGF-β/Smad signaling pathways.

Cite This Study

Yang et al. (2020) studied this question.

synapsesocial.com/papers/6a90de3517bbbfe73e74485fhttps://doi.org/10.1002/mnfr.202000231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Syringaresinol from Cinnamomum cassia (L.) J.Presl Ameliorates Cognitive Deficits and AD Pathology via AMPK in a DM-AD Mouse Model2025 · 2 citations
  2. 2Syringin Protects Against Doxorubicin‐Induced Cardiotoxicity via Apelinr‐Dependent Activation of the Nuclear Factor‐Erythroid 2‐Related Factor 2/Heme Oxygenase‐1 Antioxidant Pathway2026 · 1 citations
  3. 3Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy2017 · 119 citations
  4. 4S-Propargyl-Cysteine Attenuates Diabetic Cardiomyopathy in db/db Mice Through Activation of Cardiac Insulin Receptor Signaling2021 · 5 citations
  5. 5Syringaresinol inhibits cardiorenal fibrosis through HSP90 in a cardiorenal syndrome type 22023 · 9 citations