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September 20, 2018Biomedicine & PharmacotherapyOpen Access

Syringaldehyde treatment in rats with isoproterenol-induced cardiotoxicity diminished serum marker enzymes, lipid peroxidation, and protein carbonyl levels while improving myocardial histopathology.

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Why the study?

Does syringaldehyde protect against isoproterenol-induced cardiotoxicity in rats?

Population

Rats with isoproterenol (ISO) induced cardiotoxicity model

Comparison

Syringaldehyde at 12.5, 25, and 50 mg/kg… vs Isoproterenol (ISO) administration alone

Design

Preclinical

Key result

Syringaldehyde treatment in rats with isoproterenol-induced cardiotoxicity diminished serum marker enzymes, lipid peroxidation, and protein carbonyl levels while improving myocardial histopathology.

Authors

SSSumayya ShahzadSMSomaiya MateenPMP.M. Mubeena Mariyath

Discussion

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Member takes

Overview

Should not change clinical practice; hypothesis-generating for syringaldehyde in animal cardiotoxicity models.

Structured PICO

Does syringaldehyde protect against isoproterenol-induced cardiotoxicity in rats?

P
Population
Rats with isoproterenol-induced cardiotoxicity.
I
Intervention
Syringaldehyde (SYD) at 12.5, 25, and 50 mg/kg administered prior and simultaneous to ISO
C
Comparator
Isoproterenol (ISO) administration alone
O
Outcome
Levels of serum marker enzymes (CKMB, LDH, AST, ALT), lipid peroxidation, protein carbonyl, antioxidant defense, membrane bound ATPases, infarct size, and histopathological changessurrogate

Syringaldehyde exhibits concentration-dependent cardioprotective effects against isoproterenol-induced myocardial injury in rats via antioxidant and anti-inflammatory mechanisms.

Cite This Study

Shahzad et al. (2018) studied Isoproterenol-induced cardiotoxicity. Syringaldehyde (SYD) vs. Isoproterenol (ISO) alone was evaluated on Marker enzymes, lipid peroxidation, protein carbonyl, and histopathological changes. Syringaldehyde treatment in rats with isoproterenol-induced cardiotoxicity diminished serum marker enzymes, lipid peroxidation, and protein carbonyl levels while improving myocardial histopathology.

synapsesocial.com/papers/6aa30bb6ab449f4ca5c229dehttps://doi.org/10.1016/j.biopha.2018.09.055
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