Key result
The combination of diosgenin and exercise training significantly reduced serum lactate dehydrogenase levels and improved ECG patterns in rats with isoproterenol-induced myocardial infarction compared to isoproterenol alone.
Why the study?
Does pretreatment with diosgenin and exercise training prevent biochemical and ECG alterations in isoproterenol-induced myocardial infarction in rats?
Does pretreatment with diosgenin and exercise training prevent biochemical and ECG alterations in isoproterenol-induced myocardial infarction in rats?
The combination of diosgenin and exercise training provides synergistic cardioprotection against isoproterenol-induced myocardial infarction in rats, potentially mediated by improved lipid metabolism.
Answers are grounded in this paper and cite their sources.
Should not change practice; hypothesis-generating for diosgenin-exercise cardioprotection in ischemic models.
Objective(s) Several studies have reported improved response of exercised hearts to myocardial infarction (MI). This study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), lipids, and electrocardiographic (ECG) patterns in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Materials and Methods One hundred Wistar rats were divided into ten groups: Control rats (C), saline (S), L-cremephor (LC), exercise (E), diosgenin dissolved in L-cremephor (15 mg/kg/day) (D), exercise+ diosgenin (E+D), ISO injected (150 mg/kg) (ISO), exercise + ISO (E+ISO), diosgenin + ISO (D+ISO) and exercise+ diosgenin+ ISO (E+D+ISO). At the end of the experiment all animals anesthetized and blood samples were collected for biochemical estimation and also the ECG patterns were recorded. Results Exercise and diosgenin pretreatment significantly decreased the lactate dehydrogenase (LDH) and TBARS level in ISO injected animals. Exercise and diosgenin pretreatment significantly decreased serum total cholesterol and increased high density lipoprotein (HDL-C). ISO-treated rats showed pathological Q waves along with elevated ST segments. The altered electrocardiograms (ECG) of ISO-treated rats were also restored to near normal by diosgenin and exercise, but exercise and diosgenin had synergistic effects. Conclusion The present investigation demonstrates that combination of diosgenin and exercise exhibited significant protection against ISO induced electrocardiographical and biochemical changes. The cadioprotective mechanism(s) appear to be through changing lipid metabolism.
No takes yet. Share an insight, caveat, or question.
Salimeh et al. (2011) studied Isoproterenol-induced myocardial infarction (n=100). Diosgenin and Exercise Training vs. Isoproterenol alone was evaluated on Serum lactate dehydrogenase (LDH) levels (U/L) (p=<0.05). The combination of diosgenin and exercise training significantly reduced serum lactate dehydrogenase levels and improved ECG patterns in rats with isoproterenol-induced myocardial infarction compared to isoproterenol alone.
Synapse has enriched 10 related papers. Consider them for comparative context: