Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 13, 2017African Journal of Traditional Complementary and Alternative MedicinesOpen Access

Carnitine combined with vitamin E significantly increased coronary flow (P<0.001), reduced malondialdehyde and nitric oxide (p<0.001), and increased GSPxase and GSRase activities (p<0.001) compared to the ISO-injected group.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does carnitine combined with vitamin E protect against isoproterenol-induced myocardial infarction in rats?

Population

Rats with isoproterenol (ISO)-induced myocardial infarction (55mg/kg body weight for three successive days)

Comparison

Carnitine combined with vitamin E administered… vs Untreated rats with ISO-induced myocardial…

Design

Preclinical

Follow-up

21 days

Authors

EHEtimad HuwaitMAMaryam A. Al-Ghamdi

Discussion

Loading...

Member takes

Overview

Should not change clinical practice; leaves open further preclinical and human investigation of carnitine-vitamin E combinations.

Structured PICO

Does carnitine combined with vitamin E protect against isoproterenol-induced myocardial infarction in rats?

P
Population
Rats with isoproterenol (ISO)-induced myocardial infarction (55mg/kg body weight for three successive days)
I
Intervention
Carnitine combined with vitamin E administered continuously for 21 days
C
Comparator
Untreated rats with ISO-induced myocardial infarction and healthy control rats
O
Outcome
Coronary flow (CF), hemodynamics (rate pressure product [RPP], left ventricular developed pressure [LVDP]), serum enzymes (CK-MB, LDH), oxidative stress markers (MDA, NO, GSPxase, GSRase), and inflammatory markers (IL-6, TNF-α)surrogate

Carnitine combined with vitamin E exerts a synergistic protective effect against isoproterenol-induced myocardial infarction in a rat model by suppressing inflammation and enhancing antioxidant activity.

Cite This Study

Huwait et al. (2017) studied this question.

synapsesocial.com/papers/6a70460c35aa2c282ce19262https://doi.org/10.21010/ajtcam.v14i2.4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination of vitamin E and L-carnitine is superior in protection against isoproterenol-induced cardiac injury: histopathological evidence2018 · 7 citations
  2. 2L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction2021 · 54 citations
  3. 3Effect of vitamin E alone and in combination with lycopene on biochemical and histopathological alterations in isoproterenol-induced myocardial infarction in rats2010 · 35 citations
  4. 4Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats2019 · 20 citations
  5. 5Cardioprotective Actions of Ascorbic Acid during Isoproterenol-Induced Acute Myocardial Infarction in Rats2009 · 36 citations