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August 14, 2018Folia MorphologicaOpen Access

Combination of vitamin E and L-carnitine is superior in protection against isoproterenol-induced cardiac injury: histopathological evidence

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Key result

Combined administration of vitamin E and L-carnitine significantly ameliorated isoproterenol-induced biochemical and histopathological cardiac injury in rats.

Why the study?

Does the combination of vitamin E and L-carnitine prevent isoproterenol-induced cardiac injury in male Wistar rats?

Population

50 male Wistar rats

Comparison

Combination of vitamin E and L-carnitine… vs Control group, isoproterenol-only treated group…

Design

Preclinical, assigned to five groups

Authors

EHEtimad HuwaitKing Abdulaziz University

Discussion

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Implication

L-carnitine plus vitamin E attenuates ISO cardiotoxicity in rats; extends preclinical data but leaves open human translation.

Structured PICO

Does the combination of vitamin E and L-carnitine prevent isoproterenol-induced cardiac injury in male Wistar rats?

P
Population
50 male Wistar albino rats weighing 150-200g subjected to isoproterenol-induced cardiac injury and treated with vitamin E and L-carnitine for 4 weeks.
I
Intervention
Combination of vitamin E (100 IU/kg) and L-carnitine (100 mg/kg) administered with isoproterenol (100 mg/kg)
C
Comparator
Control group, isoproterenol-only treated group (100 mg/kg), isoproterenol + vitamin E (100 IU/kg), and isoproterenol + L-carnitine (100 mg/kg)
O
Outcome
Biochemical changes (serum cardiac enzymes, malondialdehyde, antioxidant enzymes, IL-6, TNF-a) and histopathological changes in the left ventricle wallsurrogate

The combination of vitamin E and L-carnitine provides superior protection against isoproterenol-induced cardiac injury in a rat model compared to either agent alone.

Limitations

  • Inability to assess changes in gene expression of the antioxidant profile in the cardiac muscle in all studied groups to prove the mechanism behind the augmentation of action.

Cite This Study

Etimad Huwait (2018) studied Isoproterenol-induced cardiac injury (n=50). Vitamin E and L-carnitine vs. Isoproterenol alone was evaluated on Biochemical and histopathological changes (cardiac enzymes, MDA, IL-6, TNF-a, antioxidants). Combined administration of vitamin E and L-carnitine significantly ameliorated isoproterenol-induced biochemical and histopathological cardiac injury in rats.

synapsesocial.com/papers/6a597220fe52ee7908d0fd66https://doi.org/10.5603/fm.a2018.0070
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of L‐carnitine biosynthesis and transport by methyl‐γ‐butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction2014 · 44 citations
  2. 2Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery disease2016 · 45 citations
  3. 3Cardioprotective effect of lemon grass as evidenced by biochemical and histopathological changes in experimentally induced cardiotoxicity2010 · 25 citations