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September 28, 2019Saudi Journal of Biological SciencesOpen Access

The combination of syringic acid and resveratrol ameliorated all biochemical and physical changes induced by isoproterenol, exhibiting cardioprotection.

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Why the study?

To evaluate the cardioprotective effects of syringic acid in combination with resveratrol in isoproterenol-induced myocardial infarcted rats.

Does the combination of syringic acid and resveratrol prevent isoproterenol-induced cardiotoxicity in Wistar rats?

Population

Wistar rats with isoproterenol-induced myocardial infarction

Comparison

Syringic acid vs resveratrol vs combination vs gallic acid

Design

Animal experimental study

Follow-up

30 days

Authors

MSManjunatha SammeturiSBSasi Bhusana Rao BonguSCSrinivasulu Cheemanapalli

Discussion

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Overview

May warrant preclinical follow-up on polyphenol combos; leaves open any role in human MI.

Structured PICO

Does the combination of syringic acid and resveratrol prevent isoproterenol-induced cardiotoxicity in Wistar rats?

P
Population
Wistar rats with isoproterenol (ISO)-induced myocardial infarction
I
Intervention
Oral pre-treatment with syringic acid (SA) 50 mg/kg, resveratrol (RV) 50 mg/kg, combination (COMB) of SA (25 mg/kg) and RV (25 mg/kg), or gallic acid (GA) (50 mg/kg) for 30 days
C
Comparator
ISO-injected rats without pre-treatment
O
Outcome
Biochemical markers of cardiotoxicity (CK, AST, ALT, GGT, GST, GPX, GSH, hs-CRP, uric acid, TPC) and body/heart weightssurrogate

The combination of syringic acid and resveratrol demonstrates cardioprotective effects against isoproterenol-induced myocardial infarction in a rat model.

Cite This Study

Sammeturi et al. (2019) studied this question.

synapsesocial.com/papers/6a8b93a560c8c47a9ee3d5fahttps://doi.org/10.1016/j.sjbs.2019.09.027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROTECTIVE ROLE OF CARNITINE SYNERGIZED WITH VITAMIN E AGAINST ISOPROTERENOL INDUCED CARDIAC INFARCTION IN RATS.2017 · 9 citations
  2. 2Potential protective effects of trimetazidine and quercetin on isoprenaline-induced myocardial infarction in rats2017 · 9 citations
  3. 3Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in rats2018 · 61 citations
  4. 4Protective effects ofLacticaseibacillus rhamnosuson isoprenaline-induced myocardial infarction in rats2022 · 8 citations
  5. 5Effect of vitamin E alone and in combination with lycopene on biochemical and histopathological alterations in isoproterenol-induced myocardial infarction in rats2010 · 35 citations