Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 15, 2022Journal of Applied MicrobiologyOpen Access

Lacticaseibacillus rhamnosus GG decreased cardiac troponin-I, creatine kinase-MB, CRP, and TNF-alpha levels, increased IL-10 levels, and improved ECG parameters in rats with isoprenaline-induced MI.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Myocardial infarction progresses to heart failure and myocardial fibrosis, and the gut microbiota plays an important role in ASCVD; this study investigated the protective effect of Lacticaseibacillus rhamnosus GG on isoprenaline-induced MI in rats.

Does Lacticaseibacillus rhamnosus GG prevent myocardial damage in an isoprenaline-induced myocardial infarction rat model?

Population

Four groups of seven rats

Comparison

Control vs ISO vs L. rhamnosus vs ISO + L. rhamnosus

Design

Preclinical animal study

Key result

Lacticaseibacillus rhamnosus GG decreased cardiac troponin-I, creatine kinase-MB, CRP, and TNF-alpha levels, increased IL-10 levels, and improved ECG parameters in rats with isoprenaline-induced MI.

Authors

EBErsin BeyazçiçekOBOZGE BEYAZCICEK

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for probiotic effects in experimental MI; human trials required before any clinical consideration.

Structured PICO

Does Lacticaseibacillus rhamnosus GG prevent myocardial damage in an isoprenaline-induced myocardial infarction rat model?

P
Population
28 rats divided into 4 groups to study the effects of L. rhamnosus on isoprenaline-induced myocardial infarction over 28 days.
I
Intervention
Lacticaseibacillus rhamnosus GG administered for 28 days, with ISO subcutaneous injection on days 27 and 28.
C
Comparator
Control group, ISO alone group, and L. rhamnosus alone group.
O
Outcome
Serum creatine kinase-MB, cardiac troponin-I, tumor necrosis factor-alpha, interleukin-10, C-reactive protein (CRP) levels, and ECG recordings (ST-segment elevation, R wave amplitude) evaluated 24 hours after ISO application.surrogate

Lacticaseibacillus rhamnosus GG demonstrates protective effects against isoprenaline-induced myocardial infarction in rats by reducing cardiac biomarkers and inflammation while improving ECG parameters.

Cite This Study

Beyazçiçek et al. (2022) studied Isoprenaline-induced myocardial infarction (n=28). Lacticaseibacillus rhamnosus GG vs. Isoprenaline alone and control was evaluated on Myocardial damage markers (cardiac troponin-I, creatine kinase-MB, CRP, TNF-alpha, IL-10) and ECG changes. Lacticaseibacillus rhamnosus GG decreased cardiac troponin-I, creatine kinase-MB, CRP, and TNF-alpha levels, increased IL-10 levels, and improved ECG parameters in rats with isoprenaline-induced MI.

synapsesocial.com/papers/6a9e6f2c554b0eaf29acbcd5https://doi.org/10.1093/jambio/lxac008
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction2021 · 54 citations
  2. 2Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats2019 · 20 citations
  3. 3Effect of folic acid on isoprenaline-induced myocardial injury in rats2024 · 9 citations
  4. 4(—)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac toxicity by stabilizing cardiac marker enzymes and membrane-bound ATPases2007 · 34 citations
  5. 5Potential protective effects of trimetazidine and quercetin on isoprenaline-induced myocardial infarction in rats2017 · 9 citations