Why the study?
Folic acid reduces oxidative stress, improves endothelial function, and prevents apoptosis, prompting investigation into its potentially protective effect against isoprenaline-induced myocardial injury in rats.
Does folic acid pretreatment prevent isoprenaline-induced myocardial injury in rats?
Population
Adult male Wistar albino rats
Comparison
Folic acid pretreatment vs isoprenaline alone
Design
Animal experimental study
Follow-up
7 days
Key result
Folic acid pretreatment significantly alleviated isoprenaline-induced myocardial injury in rats by decreasing homocysteine, high-sensitivity troponin I, and reactive oxygen species.
Authors
Loading...
May support cardioprotection in rat models; leaves open human translation for folic acid pretreatment.
Does folic acid pretreatment prevent isoprenaline-induced myocardial injury in rats?
Folic acid pretreatment acts as a mild antioxidant and provides cardioprotection in a rat model of isoprenaline-induced myocardial injury.
Šobot et al. (2024) studied Isoprenaline-induced myocardial injury. Folic acid vs. Isoprenaline alone was evaluated on Cardiac damage markers, oxidative stress markers, and histopathological changes. Folic acid pretreatment significantly alleviated isoprenaline-induced myocardial injury in rats by decreasing homocysteine, high-sensitivity troponin I, and reactive oxygen species.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: