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June 1, 2010Journal of Pharmacology and PharmacotherapeuticsOpen Access

Treatment with the combination of Vitamin E and lycopene for 30 days significantly attenuated biochemical and histopathological changes compared to individual treatments and ISO treated groups.

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Why the study?

Does the combination of vitamin E and lycopene improve biochemical and histopathological alterations in isoproterenol-induced myocardial infarction in rats?

Population

Adult male albino rats of Wistar strain with isoproterenol-induced myocardial infarction

Comparison

Vitamin E and lycopene in combination for 30 days vs Vitamin E alone, lycopene alone, and…

Design

Preclinical

Follow-up

30 days

Authors

AUAman UpaganlawarShri Jagannath Sanskrit UniversityHGHardik GandhiMaharaja Sayajirao University of BarodaRBR BalaramanKM Shah Dental College and Hospital

Discussion

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Overview

Hypothesis-generating for antioxidant synergy in rat MI; should not yet influence human practice.

Structured PICO

Does the combination of vitamin E and lycopene improve biochemical and histopathological alterations in isoproterenol-induced myocardial infarction in rats?

P
Population
Adult male albino rats of Wistar strain with isoproterenol-induced myocardial infarction (200 mg/kg, s.c. for 2 days)
I
Intervention
Vitamin E (100 mg/kg/day, p.o.) and lycopene (10 mg/kg/day, p.o.) in combination for 30 days
C
Comparator
Vitamin E alone, lycopene alone, and isoproterenol-treated control group
O
Outcome
Biochemical alterations (serum marker enzymes, lipid peroxidation, endogenous antioxidants, membrane bound enzymes) and histopathological changessurrogate

The combination of vitamin E and lycopene demonstrates synergistic cardioprotective effects against isoproterenol-induced myocardial infarction in a rat model.

Cite This Study

Upaganlawar et al. (2010) studied this question.

synapsesocial.com/papers/6a7042e9febe604dd7090aaehttps://doi.org/10.4103/0976-500x.64532
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination of vitamin E and L-carnitine is superior in protection against isoproterenol-induced cardiac injury: histopathological evidence2018 · 7 citations
  2. 2PROTECTIVE ROLE OF CARNITINE SYNERGIZED WITH VITAMIN E AGAINST ISOPROTERENOL INDUCED CARDIAC INFARCTION IN RATS.2017 · 9 citations
  3. 3Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats2019 · 20 citations
  4. 4Cardioprotective Actions of Ascorbic Acid during Isoproterenol-Induced Acute Myocardial Infarction in Rats2009 · 36 citations
  5. 5Protective Effect of Diosgenin and Exercise Training on Biochemical and ECG Alteration in Isoproterenol- Induced Myocardial Infarction in Rats2011 · 13 citations