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April 6, 2021Benha Medical JournalOpen Access

Sildenafil and/or Vitamin E pretreatment reduces cardiac injury and ECG alterations in rat MI models.

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Why the study?

The cardioprotective effect of sildenafil against myocardial infarction and its complications remains controversial.

Does pretreatment with sildenafil and/or vitamin E prevent isoprenaline-induced myocardial infarction in male rats?

Population

5 groups of male rats

Comparison

Oral sildenafil, oral vitamin E, or both vs control and isoprenaline alone

Design

Animal experimental study

Key result

Pretreatment with Sildenafil and/or Vitamin E significantly ameliorated ECG alterations, decreased CK-MB, and reduced cardiac injury scores in isoprenaline-induced myocardial infarction in rats.

Authors

HYHeba S. YoussefMMMarwa MuhammadMSMona A. Said

Discussion

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Member takes

Overview

May support further preclinical study of sildenafil or vitamin E; hypothesis-generating and should not change practice.

Structured PICO

Does pretreatment with sildenafil and/or vitamin E prevent isoprenaline-induced myocardial infarction in male rats?

P
Population
Male rats divided into 5 groups to evaluate the prophylactic effect of Sildenafil and/or Vitamin E on isoprenaline-induced myocardial infarction.
I
Intervention
Oral Sildenafil (10mg/kg/day) and/or oral Vitamin E (100IU/kg/day) for 3 weeks before injection of ISO
C
Comparator
Control group and ISO-injected group without pretreatment
O
Outcome
ECG alterations, serum CK-MB, cardiac injury score, histopathological changes, cardiac SOD and MDA content, and TGFβ expressionsurrogate

Sildenafil and/or vitamin E pretreatment showed prophylactic cardioprotective and antifibrotic effects against isoprenaline-induced myocardial infarction in a rat model.

Cite This Study

Youssef et al. (2021) studied Isoprenaline-induced Myocardial Infarction. Sildenafil and/or Vitamin E vs. Isoprenaline-injected group without pretreatment was evaluated on ECG alterations, serum CK-MB levels, and cardiac injury score. Pretreatment with Sildenafil and/or Vitamin E significantly ameliorated ECG alterations, decreased CK-MB, and reduced cardiac injury scores in isoprenaline-induced myocardial infarction in rats.

synapsesocial.com/papers/6aa6cc7b5becb0bc28eee16ehttps://doi.org/10.21608/bmfj.2021.67015.1393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sildenafil after cardiac arrest and infarction; an experimental rat model2012 · 5 citations
  2. 2Effect of vitamin D on isoprenaline-induced myocardial infarction in rats: possible role of peroxisome proliferator-activated receptor-γ2017 · 27 citations
  3. 3Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice2007 · 188 citations
  4. 4Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice2008 · 108 citations
  5. 5Cardioprotective Actions of Ascorbic Acid during Isoproterenol-Induced Acute Myocardial Infarction in Rats2009 · 36 citations