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January 22, 2017Canadian Journal of Physiology and PharmacologyOpen Access

Effect of vitamin D on isoprenaline-induced myocardial infarction in rats: possible role of peroxisome proliferator-activated receptor-γ

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Why the study?

Does pretreatment with vitamin D prevent isoprenaline-induced myocardial infarction in rats?

Population

Rats with isoprenaline-induced myocardial infarction (infarct-like lesions)

Comparison

Pretreatment with vitamin D vs Isoprenaline alone, and vitamin D + bisphenol A…

Design

Preclinical

Authors

OEOla A. El-GoharyMAMona M. Allam

Discussion

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Overview

Should not change MI prevention practice; leaves open PPAR-γ mediation in human translation from rat models.

Structured PICO

Does pretreatment with vitamin D prevent isoprenaline-induced myocardial infarction in rats?

P
Population
Rats with isoprenaline-induced myocardial infarction (infarct-like lesions)
I
Intervention
Pretreatment with vitamin D
C
Comparator
Isoprenaline alone, and vitamin D + bisphenol A diglycidyl ether (BADGE, a PPAR-γ antagonist)
O
Outcome
Cardiac damage assessed by serum creatine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), cardiac malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH), ECG monitoring (ST-segment elevation), and injury extensionsurrogate

Vitamin D provides cardioprotection against isoprenaline-induced myocardial infarction in rats, likely mediated through PPAR-γ activation.

Cite This Study

El-Gohary et al. (2017) studied this question.

synapsesocial.com/papers/6a7cab72e98c86b2617ccfdchttps://doi.org/10.1139/cjpp-2016-0150
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Also Consider

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