Key result
Pretreatment with vanillin significantly suppressed isoprenaline-induced pathological changes, including elevated levels of cTn-I, LDH, and CK-MB, and reduced cardiac and renal oxidative stress.
Why the study?
Does pretreatment with vanillin reduce cardiac and renal damage in a rat model of isoprenaline-induced myocardial infarction?
Does pretreatment with vanillin reduce cardiac and renal damage in a rat model of isoprenaline-induced myocardial infarction?
Vanillin demonstrates potential cardio- and reno-protective effects against isoprenaline-induced myocardial infarction in a rat model.
Should not change clinical practice for myocardial protection; leaves open vanillin's role in further experimental models.
Myocardial infarction (MI) continues to be a major public health problem in the world. Vanillin is a natural phenolic compound that possesses significant anti-oxidant and anti-inflammatory activities. The present study aimed to investigate the effects of pretreatment with vanillin (150 mg/kg, p.o.) and vanillin (300 mg/kg, p.o.) on isoprenaline-induced MI in rats. Markers chosen to assess cardiac damage included serum activity of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH), in addition to serum level of cardiac troponin-I (cTn-I), as well as antioxidant activity of cardiac catalase (CAT) as well as cardiac contents of RGH, lipid peroxides, and nitrite. Furthermore Electrocardiograph (ECG) monitoring and histological examinations of cardiac tissues were done. In addition markers chosen to assess renal impairment included serum and urine levels of creatinin, blood urea nitrogen (BUN), also creatinine clearance (Ccr), urea clearance (Ucr) and glomerular filteration rate (GFR) were assessed. In addition, antioxidant activity of renal CAT and renal contents of RGH, lipid peroxides, and nitrite. Furthermore, histological examinations of renal tissues were done. Isoprenaline increased serum CK-MB and LDH activity and cTn-I level, cardiac and renal oxidative stress biomarkers. In addition, it produced ST-segment elevation and degenerative changes in heart and renal tissues. Pretreatment with vanillin in previous doses significantly suppressed isoprenaline-induced pathological changes, as the elevated levels of cTn-I, LDH and CK-MB in serum coupled with reduction in cardiac and renal oxidative stress markers. Moreover marked improvement in ECG and histopathologic alterations in both cardiac and renal tissues were produced. In conclusion, vanillin can be regarded as a promising cardio- and reno- protective natural agent in MI.
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Haleem et al. (2015) studied Isoprenaline-induced myocardial infarction. Vanillin vs. Isoprenaline alone was evaluated on Cardiac and renal damage markers including CK-MB, LDH, cTn-I, and oxidative stress biomarkers. Pretreatment with vanillin significantly suppressed isoprenaline-induced pathological changes, including elevated levels of cTn-I, LDH, and CK-MB, and reduced cardiac and renal oxidative stress.
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