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September 20, 2012Scandinavian Cardiovascular JournalOpen Access

Sildenafil at reperfusion improves remote intramyocardial artery preservation by ~32% in a rat model.

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Why the study?

Does sildenafil improve myocardial recovery in a rat model of cardiac arrest and infarction?

Population

84 Fischer344 rats undergoing syngeneic heterotopic cardiac transplantation

Comparison

Subcutaneously injected sildenafil administered… vs Ischemia reperfusion injury + myocardial…

Design

Preclinical

Follow-up

2 days

Key result

Sildenafil administered at the onset of reperfusion improved preservation of remote intramyocardial arteries compared to controls (0.74 vs 0.56 PSU, p<0.05) in a rat cardiac transplantation model.

Authors

AMAri MennanderVVVilma VuohelainenRÄRiikka Äänismaa

Discussion

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Overview

Sildenafil may support vascular preservation post-arrest in rats; leaves open any role for PDE5 inhibition in human resuscitation.

Structured PICO

Does sildenafil improve myocardial recovery in a rat model of cardiac arrest and infarction?

P
Population
84 Fischer344 rats undergoing syngeneic heterotopic cardiac transplantation after ischemia and myocardial infarction, followed for 2 days.
I
Intervention
Subcutaneously injected sildenafil (1 mg/kg/day) administered at the onset of reperfusion
C
Comparator
Ischemia reperfusion injury + myocardial infarction without sildenafil, and ischemia reperfusion injury only
O
Outcome
Myocardial recovery assessed by immunohistochemistry for eNOS, RT-PCR for iNOS and Aquaporin-7, and histology at 2 dayssurrogate

Main Result

Absolute Event Rate: 0.74% vs 0.56%

p-value: p=< 0.05

In a rat model of cardiac arrest and infarction, sildenafil administered at the onset of reperfusion improved myocardial recovery and reduced iNOS expression.

Cite This Study

Mennander et al. (2012) studied Cardiac arrest and infarction (n=84). Sildenafil vs. Ischemia-reperfusion injury with or without myocardial infarction was evaluated on Preservation of remote intramyocardial arteries (PSU) (p=< 0.05). Sildenafil administered at the onset of reperfusion improved preservation of remote intramyocardial arteries compared to controls (0.74 vs 0.56 PSU, p<0.05) in a rat cardiac transplantation model.

synapsesocial.com/papers/6aa93ecd86badb2eb40e02c3https://doi.org/10.3109/14017431.2012.732235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sildenafil Protects against Myocardial Ischemia-Reperfusion Injury Following Cardiac Arrest in a Porcine Model: Possible Role of the Renin-Angiotensin System2015 · 24 citations
  2. 2The protective effects of a phosphodiesterase 5 inhibitor, sildenafil, on postresuscitation cardiac dysfunction of cardiac arrest: metabolic evidence from microdialysis2014 · 17 citations
  3. 3Administration of Sildenafil at Reperfusion Fails to Reduce Infarct Size: Results from the CAESAR Cardioprotection Consortium (LB650)2014 · 20 citations
  4. 4Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice2007 · 188 citations
  5. 5Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice2008 · 108 citations