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March 1, 2010Journal of Pharmacy and PharmacologyOpen Access

Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart

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Why the study?

Does sildenafil improve post-ischaemic left ventricular function in a rat isolated heart model?

Population

36 Wistar rats (290 +/- 7 g)

Comparison

Sildenafil administered 30 min before ischaemia… vs Control group (n=12 rats)

Design

Preclinical

Authors

TKTheofilos M. KolettisUniversity of IoanninaKKKonstantinos KontarasHellenic Red CrossISIoannis Spartinos

Discussion

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Implication

Acute low-dose sildenafil may aid post-ischaemic recovery in rats but chronic use may harm it; leaves clinical translation open.

Structured PICO

Does sildenafil improve post-ischaemic left ventricular function in a rat isolated heart model?

P
Population
36 Wistar rats (290 +/- 7 g)
I
Intervention
Sildenafil administered 30 min before ischaemia at a low (0.7 mg/kg, n=8) or high (1.4 mg/kg, n=8) dosage, or chronic treatment consisting of two daily injections of sildenafil (0.7 mg/kg) for three weeks (n=8)
C
Comparator
Control group (n=12 rats)
O
Outcome
Post-ischaemic recovery of left ventricular function (developed pressure), ischaemic contracture, and hypercontracture in isolated, Langendorff-perfused preparationssurrogate

Sildenafil exhibits dose-dependent effects on post-ischaemic left ventricular function in rats, with acute low doses providing benefit while chronic administration worsens function.

Cite This Study

Kolettis et al. (2010) studied this question.

synapsesocial.com/papers/6a813e61ec86ba91653bfc3dhttps://doi.org/10.1211/jpp.62.03.0009
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Also Consider

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