Why the study?
Does sildenafil attenuate LV remodeling and prevent exercise intolerance in a rat model of chronic mitral regurgitation?
Population
Sprague-Dawley rats with chronic mitral regurgitation, n=48.
Comparison
Sildenafil 50 mg/kg PO twice a day for 4 months vs Normal saline only for 4 months
Design
Preclinical, randomly assigned
Follow-up
4 months
Authors
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Hypothesis-generating for PDE5 inhibition in mitral regurgitation; human trials required before any clinical consideration.
Does sildenafil attenuate LV remodeling and prevent exercise intolerance in a rat model of chronic mitral regurgitation?
Sildenafil attenuates LV remodeling and prevents exercise intolerance in a rat model of chronic mitral regurgitation, potentially via antiapoptotic and anti-inflammatory effects.
Kim et al. (2012) studied this question.
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