Why the study?
Does sildenafil and/or muscle-derived stem cells improve left ventricular function and attenuate remodeling in a rat model of myocardial infarction?
Population
Rats with myocardial infarction induced by ligature of the left anterior descending coronary artery
Comparison
Oral sildenafil 3 mg/kg/day from day 1 and/or… vs Untreated MI rats or intracardiac saline injection
Design
Preclinical
Follow-up
4 weeks
Authors
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Should not change post-MI care; hypothesis-generating for sildenafil or MDSC monotherapy in rat models.
Does sildenafil and/or muscle-derived stem cells improve left ventricular function and attenuate remodeling in a rat model of myocardial infarction?
In a rat model of myocardial infarction, sildenafil or muscle-derived stem cells alone improved LV function and reduced fibrosis, but their combination was ineffective.
Wang et al. (2012) studied this question.
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