Key result
Chronic sildenafil treatment initiated 3 days post-myocardial infarction preserved fractional shortening and significantly reduced myocardial fibrosis to 5.8% compared to 18.9% with saline at 28 days.
Why the study?
Does sildenafil improve left ventricular function and remodeling in a mouse model of post-myocardial infarction heart failure?
Population
113 adult male ICR mice with fractional shortening < 25% at day 3 following permanent left anterior…
Comparison
Sildenafil 21 mg/kg intraperitoneally twice… vs Volume-matched saline intraperitoneally twice…
Design
Preclinical, randomly assigned to one of six treatment groups
Follow-up
28 days post-MI
Authors
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Sildenafil initiated 3 days post-MI attenuates HF progression in mice; extends immediate-treatment data and supports RhoA/Rho-kinase as a therapeutic target for further study.
Does sildenafil improve left ventricular function and remodeling in a mouse model of post-myocardial infarction heart failure?
p-value: p=<0.05
Delayed chronic sildenafil treatment initiated 3 days post-myocardial infarction attenuates left ventricular dysfunction and adverse remodeling in mice via inhibition of the RhoA/Rho-kinase pathway.
Chau et al. (2011) studied Heart failure post-myocardial infarction (n=113). Sildenafil vs. Saline (volume matched, ip, 2 times/day) was evaluated on Fractional shortening at 7 and 28 days post-MI (p=<0.05). Chronic sildenafil treatment initiated 3 days post-myocardial infarction preserved fractional shortening and significantly reduced myocardial fibrosis to 5.8% compared to 18.9% with saline at 28 days.
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