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March 1, 2008AJP Heart and Circulatory Physiology

Sildenafil significantly reduced infarct size (40.0 ± 4.6% vs 69.6 ± 4.1%, P < 0.05) and improved survival rate (93% vs 36%, P < 0.05) compared with saline.

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Why the study?

Does sildenafil attenuate ischemic cardiomyopathy and improve left ventricular function in mice post-myocardial infarction?

Population

ICR mice undergoing myocardial infarction (MI) by left anterior descending coronary artery ligation

Comparison

Sildenafil (0.71 mg/kg bid) for 4 weeks vs Saline for 4 weeks

Design

Preclinical

Follow-up

4 weeks

Authors

FSFadi N. SalloumAAAntonio AbbateADAnindita Das

Discussion

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Overview

Should not change post-MI therapy; leaves open translation of sildenafil benefits from this mouse model.

Structured PICO

Does sildenafil attenuate ischemic cardiomyopathy and improve left ventricular function in mice post-myocardial infarction?

P
Population
ICR mice undergoing myocardial infarction (MI) by left anterior descending coronary artery ligation
I
Intervention
Sildenafil (0.71 mg/kg bid) for 4 weeks
C
Comparator
Saline for 4 weeks
O
Outcome
Infarct size (IS) measured 24 h postinfarctionsurrogate

Sildenafil attenuates ischemic cardiomyopathy and improves survival in a mouse model of myocardial infarction, likely via a nitric oxide-dependent pathway.

Cite This Study

Salloum et al. (2008) studied this question.

synapsesocial.com/papers/6a76243cfd97cd3fd98c5d7dhttps://doi.org/10.1152/ajpheart.ajpheart.91438.2007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice2007 · 188 citations
  2. 2Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway2011 · 75 citations
  3. 3Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart2010 · 17 citations
  4. 4Sildenafil after cardiac arrest and infarction; an experimental rat model2012 · 5 citations
  5. 5Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity2005 · 354 citations