Why the study?
Does sildenafil reduce myocardial infarct size in preclinical models of myocardial ischemia and reperfusion?
Population
Mouse, rabbit, and pig models of myocardial ischemia and reperfusion
Comparison
Sildenafil administered intravenously as a bolus… vs Control group (implied by randomized design)
Design
Preclinical, Randomized, Blinded
Authors
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Sildenafil lacks support for infarct size reduction in rigorous animal models; challenges earlier reports and leaves clinical translation open.
Does sildenafil reduce myocardial infarct size in preclinical models of myocardial ischemia and reperfusion?
Sildenafil administered at reperfusion does not reduce infarct size in standardized, rigorous preclinical models of myocardial ischemia and reperfusion.
Kukreja et al. (2014) studied this question.
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