Key result
Sildenafil (0.5 mg/kg) ameliorated reduced cardiac function and improved the 24-hour survival rate in a porcine cardiac arrest and resuscitation model.
Why the study?
Does sildenafil improve cardiac function and survival in a porcine model of cardiac arrest and resuscitation?
Population
Male pigs in a cardiac arrest and resuscitation model
Comparison
Sildenafil infused 30 min before ventricular… vs Saline infusion and Sham procedure
Design
Preclinical, randomly divided
Follow-up
24 hours
Authors
Loading...
Hypothesis-generating in porcine arrest; leaves open translation to human resuscitation pending trials.
RCT
Randomized
Does sildenafil improve cardiac function and survival in a porcine model of cardiac arrest and resuscitation?
Sildenafil protects against myocardial ischemia-reperfusion injury and improves 24-hour survival in a porcine cardiac arrest model, potentially by inhibiting the Ang II-AT1R axis.
Wang et al. (2015) conducted an RCT in Myocardial ischemia-reperfusion injury following cardiac arrest. Sildenafil vs. Sham and Saline was evaluated on Cardiac function and 24-h survival rate. Sildenafil (0.5 mg/kg) ameliorated reduced cardiac function and improved the 24-hour survival rate in a porcine cardiac arrest and resuscitation model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: