April 27, 2016Journal of Translational MedicineOpen Access

Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

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Why the study?

Does early administration of trimetazidine ameliorate diabetic cardiomyopathy in a rat model?

Structured PICO

Does early administration of trimetazidine ameliorate diabetic cardiomyopathy in a rat model?

Population

Type 2 diabetic cardiomyopathy rat model established by high-fat diet and low-dose streptozotocin (n=18 total, n=6 per group)

Intervention

Trimetazidine (early administration)

Comparator

Diabetic rats without trimetazidine, and healthy controls

Outcome

Cardiac autophagy, cardiac functions, and cardiomyocyte apoptosissurrogate

Early administration of trimetazidine in a rat model of type 2 diabetic cardiomyopathy ameliorates the condition by inhibiting myocardial fibrosis and apoptosis while enhancing autophagy.

Authors

LZLei ZhangSouthwest Medical University WDWenyuan DingHebei Medical University ZWZhihao WangChina West Normal University

Discussion

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Implication

May attenuate fibrosis in diabetic rat hearts; leaves open human translation pending trials.

Cite This Study

Zhang et al. (2016) studied this question.

synapsesocial.com/papers/6a085bb73d5e33e4691082f2 https://doi.org/10.1186/s12967-016-0849-1

View Full Paper

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Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

Structured PICO

Discussion

Implication

Cite This Study

Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider