Key result
Trimetazidine attenuated metabolic remodeling and improved cardiac function in isoproterenol-induced heart failure rats by regulating ketone body metabolism via activation of AMPK and PPARα.
Why the study?
This study was conducted to assess the effects and mechanisms of trimetazidine on ketone body metabolism in heart failure rats.
Does trimetazidine improve cardiac function and metabolic remodeling in isoproterenol-induced heart failure rats?
Does trimetazidine improve cardiac function and metabolic remodeling in isoproterenol-induced heart failure rats?
Trimetazidine ameliorates myocardial metabolic remodeling and improves cardiac function in a rat model of heart failure by regulating ketone body metabolism via the AMPK/PPARα signaling pathway.
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Hypothesis-generating in rat HF models; leaves open clinical translation of trimetazidine via AMPK/PPARα.
Li et al. (2020) studied Isoproterenol-induced heart failure (n=36). Trimetazidine vs. Normal saline was evaluated on Cardiac function and metabolic remodeling (including HWI, BNP, and LVEF). Trimetazidine attenuated metabolic remodeling and improved cardiac function in isoproterenol-induced heart failure rats by regulating ketone body metabolism via activation of AMPK and PPARα.
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