Key result
Trimetazidine significantly reduced infarct size compared to ischemia without treatment (31.24% vs. 52.87%) and preserved mitochondrial function in rats with acute myocardial ischemia.
Why the study?
Does trimetazidine reduce infarct size and preserve mitochondrial function in a rat model of acute myocardial ischemia?
Population
Rat model of acute myocardial ischemia
Comparison
Trimetazidine 10 mg/kg/d orally by gavage for 7… vs Ischemia group without trimetazidine…
Design
Preclinical
Follow-up
7 days
Authors
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Hypothesis-generating in rat ischemia; leaves open translation to human acute MI therapy.
Does trimetazidine reduce infarct size and preserve mitochondrial function in a rat model of acute myocardial ischemia?
Absolute Event Rate: 31.24% vs 52.87%
Trimetazidine demonstrates cardioprotective effects in a rat model of acute myocardial ischemia by preserving mitochondrial function and reducing infarct size.
Wen Shi (2017) studied Acute myocardial ischemia. Trimetazidine vs. Ischemia group without trimetazidine administration was evaluated on Infarct size. Trimetazidine significantly reduced infarct size compared to ischemia without treatment (31.24% vs. 52.87%) and preserved mitochondrial function in rats with acute myocardial ischemia.
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