Why the study?
Does trimetazidine improve mitochondrial function and reduce oxidative damage in isolated ischemic hypertrophied rat hearts?
Population
Isolated rat hearts subjected to moderate ischemia and reperfusion stress
Comparison
Trimetazidine (0.1-10 mumol/l) vs Control (no trimetazidine)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for trimetazidine in hypertrophied hearts; prospective human studies needed before clinical adoption.
Does trimetazidine improve mitochondrial function and reduce oxidative damage in isolated ischemic hypertrophied rat hearts?
Trimetazidine protects against ischemia/reperfusion-induced energetic and oxidative damage in hypertrophied rat hearts by preserving mitochondrial function.
Guarnieri et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: