Key result
Non-opioid approaches including neuroimmune modulators and peptide disruptors offer potential surgical pain relief without opioid risks.
Why the study?
The opioid epidemic has highlighted the increasing need for alternative pain relievers in surgical settings.
This review outlines emerging biochemical strategies for opioid-sparing pain management in the operating room.
Supports further study of neuroimmune modulators for surgical pain; leaves open clinical adoption pending prospective trials.
The opioid epidemic has highlighted the increasing need for alternative pain relievers in surgical settings. This review explores non-opioid approaches for managing pain in the ever-changing operating room. The review examines the molecular basis of pain perception, with a focus on receptor-targeted treatments that offer effectiveness without the risks associated with opioids. Despite the demonstrated benefits and improved side effect profiles, our literature analysis reveals the challenges that hinder the integration of innovative pain relievers. We explore the potential of neuroimmune modulators, peptide disruptors, and new neurotransmitter analogs in the quest for effective pain relief, paving the way for a future of anesthesia without opioids.
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Hosseinzadeh et al. (2025) conducted a review in Pain management in surgical settings. Non-opioid approaches (neuroimmune modulators, peptide disruptors, neurotransmitter analogs) vs. Opioids was evaluated. Non-opioid approaches, including neuroimmune modulators and peptide disruptors, offer potential for effective pain relief in surgical settings without the risks associated with opioids.
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