Congestion and inflammation indexes were independent predictors of 90-day all-cause mortality in patients with acute heart failure (hazard ratios 1.4 and 2.3, respectively).
Cohort (n=314)
Do congestion and inflammation indexes predict 90-day all-cause mortality in patients with acute heart failure?
Both congestion and systemic inflammation indexes are independent predictors of 90-day mortality in patients with acute heart failure.
Effect estimate: HR 1.4 and 2.3
Background: The reciprocal correlation between systemic inflammation and heart failure (HF) is a hotline research topic although the exact role in risk stratification and prognosis within the acute setting is a matter of debate. This study aimed to evaluate the correlation among two inflammatory biomarkers-namely, high-sensitivity C-reactive protein (hs-CRP) and neutrophil-lymphocyte ratio (NLR), congestion status, and prognosis in patients with acute HF (AHF). Methods: We consecutively enrolled 314 AHF patients. Congestion biomarkers brain natriuretic peptide, estimated plasma volume status (ePVS), hydration index (HI), blood urea nitrogen to creatinine ratio (BUN/Cr) were evaluated to assess hemodynamic intravascular, peripheral, and venous congestion. We also measured hs-CRP and NLR as markers of inflammation. The endpoint was all-cause mortality at 90 days. Results: 60 pg/mL and >7.5, respectively) were predictors of death. By using all these parameters, we performed an index of inflammation (from 0 to 2) for each patient. Congestion and inflammation indexes were independent predictors of mortality (hazard ratios 1.4 and 2.3, respectively; C-index 0.72). Conclusion: Systemic inflammation seemed directly associated with congestion burden in patients with AHF. Both of them have different impacts on the prediction of adverse outcomes in these patients. Further studies are needed to address unmet needs.
Scicchitano et al. (Mon,) conducted a cohort in acute heart failure (AHF) (n=314). Congestion and inflammation indexes was evaluated on all-cause mortality at 90 days (HR 1.4 and 2.3). Congestion and inflammation indexes were independent predictors of 90-day all-cause mortality in patients with acute heart failure (hazard ratios 1.4 and 2.3, respectively).