Cardiac Energy Metabolic Alterations in Pressure Overload–Induced Left and Right Heart Failure (2013 Grover Conference Series)
Key result
Pressure overload-induced HF features energy deficiency driven by reduced mitochondrial oxidative metabolism and increased glycolysis.
Population
Left and right heart failure induced by pressure overload
Design
Review
Authors
Discussion
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Implication
Metabolic shift in pressure overload HF may identify therapeutic targets; leaves open whether interventions improve clinical outcomes.
Structured PICO
P
Population
Left and right heart failure induced by pressure overload (pulmonary hypertension and/or systemic hypertension)
I
Intervention
Pharmacological approaches targeting energy metabolism
Optimizing cardiac energy metabolism, specifically addressing the shift from mitochondrial oxidation to glycolysis, represents a potential therapeutic target for pressure overload-induced heart failure.
Cite This Study
Sankaralingam et al. (2015) conducted a review in Pressure overload-induced left and right heart failure. Pressure overload-induced heart failure is characterized by an energy deficiency driven by reduced mitochondrial oxidative metabolism and increased reliance on glycolysis.